Genome-wide impact of hydrogen peroxide on maintenance DNA methylation in replicating cells

Genome-wide impact of hydrogen peroxide on maintenance DNA methylation in replicating cells

Abstract Background Environmental factors, such as oxidative stress, have the potential to modify the epigenetic landscape of cells. We have previously shown that DNA methyltransferase (DNMT) activity can be inhibited by sublethal doses of hydrogen peroxide (H2O2). However, site-specific changes in...

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Bibliographic Details
Main Authors: Annika R. Seddon, Yusmiati Liau, Paul E. Pace, Allison L. Miller, Andrew B. Das, Martin A. Kennedy, Mark B. Hampton, Aaron J. Stevens
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Epigenetics & Chromatin
Subjects:
DNA methylation
DNA methyltransferase
Epigenetics
Oxidative stress
Hydrogen peroxide
Cancer
Online Access:https://doi.org/10.1186/s13072-021-00388-6

Internet

https://doi.org/10.1186/s13072-021-00388-6

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