Connexin26 hemichannels with a mutation that causes KID syndrome in humans lack sensitivity to CO2

Connexin26 hemichannels with a mutation that causes KID syndrome in humans lack sensitivity to CO2

Mutations in connexin26 (Cx26) underlie a range of serious human pathologies. Previously we have shown that Cx26 hemichannels are directly opened by CO2 (Meigh et al., 2013). However the effects of human disease-causing mutations on the CO2 sensitivity of Cx26 are entirely unknown. Here, we report t...

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Bibliographic Details
Main Authors: Louise Meigh, Naveed Hussain, Daniel K Mulkey, Nicholas Dale
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-11-01
Series:eLife
Subjects:
respiratory apnea
CO2 chemosensing
gap junction
hemichannels
Online Access:https://elifesciences.org/articles/04249

Internet

https://elifesciences.org/articles/04249

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