Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium

Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium

Summary: Either caspase-1 or caspase-11 can cleave gasdermin D to cause pyroptosis, eliminating intracellular replication niches. We previously showed that macrophages detect Burkholderia thailandensis via NLRC4, triggering the release of interleukin (IL)-18 and driving an essential interferon (IFN)...

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Bibliographic Details
Main Authors: Stephen B. Kovacs, Changhoon Oh, Vivien I. Maltez, Benjamin D. McGlaughon, Ambika Verma, Edward A. Miao, Youssef Aachoui
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Cell Reports
Subjects:
inflammasome
pyropotosis
caspase-1
caspase-11
NLRC4
neutrophil
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720309487

Internet

http://www.sciencedirect.com/science/article/pii/S2211124720309487

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