DNA Methylation Biomarkers Predict Objective Responses to PD-1/PD-L1 Inhibition Blockade

DNA Methylation Biomarkers Predict Objective Responses to PD-1/PD-L1 Inhibition Blockade

Immune checkpoint inhibitor (ICI) treatment could bring long-lasting clinical benefits to patients with metastatic cancer. However, only a small proportion of patients respond to PD-1/PD-L1 blockade, so predictive biomarkers are needed. Here, based on DNA methylation profiles and the objective respo...

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Bibliographic Details
Main Authors: Gang Xue, Ze-Jia Cui, Xiong-Hui Zhou, Yue-Xing Zhu, Ying Chen, Feng-Ji Liang, Da-Nian Tang, Bing-Yang Huang, Hong-Yu Zhang, Zhi-Huang Hu, Xi-Yu Yuan, Jianghui Xiong
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Genetics
Subjects:
PD-1/PD-L1 inhibition therapy
objective response rate
DNA methylation
biomarkers
Lasso model
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00724/full

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https://www.frontiersin.org/article/10.3389/fgene.2019.00724/full

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