Decreasing cytosolic translation is beneficial to yeast and human Tafazzin-deficient cells

Decreasing cytosolic translation is beneficial to yeast and human Tafazzin-deficient cells

Cardiolipin (CL) optimizes diverse mitochondrial processes, including oxidative phosphorylation (OXPHOS). To function properly, CL needs to be unsaturated, which requires the acyltransferase Tafazzin (TAZ). Loss-of-function mutations in the TAZ gene are responsible for the Barth syndrome (BTHS), a r...

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Bibliographic Details
Main Authors: Maxence de Taffin de Tilques, Jean-Paul Lasserre, François Godard, Elodie Sardin, Marine Bouhier, Marina Le Guedard, Roza Kucharczyk, Patrice X. Petit, Eric Testet, Jean-Paul di Rago, Déborah Tribouillard-Tanvier
Format: Article
Language:English
Published: Shared Science Publishers OG 2018-02-01
Series:Microbial Cell
Subjects:
mitochondrial disease
oxidative phosphorylation
Barth syndrome
cytosolic protein synthesis
cycloheximide
cardiolipin remodeling
Online Access:http://microbialcell.com/researcharticles/decreasing-cytosolic-translation-is-beneficial-to-yeast-and-human-tafazzin-deficient-cells/

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http://microbialcell.com/researcharticles/decreasing-cytosolic-translation-is-beneficial-to-yeast-and-human-tafazzin-deficient-cells/

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