NBM-T-BMX-OS01, an Osthole Derivative, Sensitizes Human Lung Cancer A549 Cells to Cisplatin through AMPK-Dependent Inhibition of ERK and Akt Pathway

NBM-T-BMX-OS01, an Osthole Derivative, Sensitizes Human Lung Cancer A549 Cells to Cisplatin through AMPK-Dependent Inhibition of ERK and Akt Pathway

Background: Drug combination therapies using cisplatin and natural products are common practice in the treatment of human lung cancer. Osthole is a natural compound extracted from a number of medicinal plants and has been shown to exert strong anticancer activities with low toxicity. Methods: In the...

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Bibliographic Details
Main Authors: Tian-Jun Chen, Yue-Fei Zhou, Jie-Juan Ning, Tian Yang, Hui Ren, Yang Li, Shuo Zhang, Ming-Wei Chen
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
A549 cells
Cisplatin
ERK
Akt
AMPK
Oxidative stress
Online Access:http://www.karger.com/Article/FullText/430264

Internet

http://www.karger.com/Article/FullText/430264

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