A randomized pilot study of L-arginine infusion in severe falciparum malaria: preliminary safety, efficacy and pharmacokinetics.

A randomized pilot study of L-arginine infusion in severe falciparum malaria: preliminary safety, efficacy and pharmacokinetics.

Decreased nitric oxide (NO) and hypoargininemia are associated with severe falciparum malaria and may contribute to severe disease. Intravenous L-arginine increases endothelial NO in moderately-severe malaria (MSM) without adverse effects. The safety, efficacy and pharmacokinetics of L-arginine or o...

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Bibliographic Details
Main Authors: Tsin W Yeo, Daniel A Lampah, Indri Rooslamiati, Retno Gitawati, Emiliana Tjitra, Enny Kenangalem, Ric N Price, Stephen B Duffull, Nicholas M Anstey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3726665?pdf=render

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http://europepmc.org/articles/PMC3726665?pdf=render

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