An Alanine-to-Valine Substitution in the Residue 175 of Zika Virus NS2A Protein Affects Viral RNA Synthesis and Attenuates the Virus In Vivo

An Alanine-to-Valine Substitution in the Residue 175 of Zika Virus NS2A Protein Affects Viral RNA Synthesis and Attenuates the Virus In Vivo

The recent outbreaks of Zika virus (ZIKV), its association with Guillain–Barré syndrome and fetal abnormalities, and the lack of approved vaccines and antivirals, highlight the importance of developing countermeasures to combat ZIKV disease. In this respect, infectious clones co...

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Bibliographic Details
Main Authors: Silvia Márquez-Jurado, Aitor Nogales, Ginés Ávila-Pérez, Francisco J. Iborra, Luis Martínez-Sobrido, Fernando Almazán
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Viruses
Subjects:
Zika virus
Full-length cDNA infectious clones
Bacterial artificial chromosome
NS2A protein
Online Access:http://www.mdpi.com/1999-4915/10/10/547

Internet

http://www.mdpi.com/1999-4915/10/10/547

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