A polymorphic helix of a Salmonella needle protein relays signals defining distinct steps in type III secretion.

Type III protein-secretion machines are essential for the interactions of many pathogenic or symbiotic bacterial species with their respective eukaryotic hosts. The core component of these machines is the injectisome, a multiprotein complex that mediates the selection of substrates, their passage th...

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Bibliographic Details
Main Authors: Emily Z Guo, Daniel C Desrosiers, Jan Zalesak, James Tolchard, Mélanie Berbon, Birgit Habenstein, Thomas Marlovits, Antoine Loquet, Jorge E Galán
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-07-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000351