Memory T cell, exhaustion, and tumor immunity

CD8+T cells are important in protective immunity against intracellular pathogens and tumors. In chronic infections or cancer, CD8+T cells are constantly exposed to antigens and inflammatory signals. Such excessive and constitutive signals lead to the deterioration of T cell function, called ‘exhaust...

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Bibliographic Details
Main Authors: Makoto Ando, Minako Ito, Tanakorn Srirat, Taisuke Kondo, Akihiko Yoshimura
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Immunological Medicine
Subjects:
Online Access:http://dx.doi.org/10.1080/25785826.2019.1698261