Forced expression of miR-143 and -145 in cardiomyocytes induces cardiomyopathy with a reductive redox shift

Forced expression of miR-143 and -145 in cardiomyocytes induces cardiomyopathy with a reductive redox shift

Abstract Background Animal model studies show that reductive stress is involved in cardiomyopathy and myopathy, but the exact physiological relevance remains unknown. In addition, the microRNAs miR-143 and miR-145 have been shown to be upregulated in cardiac diseases, but the underlying mechanisms a...

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Bibliographic Details
Main Authors: Kota Ogawa, Akiko Noda, Jun Ueda, Takehiro Ogata, Rumiko Matsuyama, Yuji Nishizawa, Shanlou Qiao, Satoru Iwata, Morihiro Ito, Yoshitaka Fujihara, Masatoshi Ichihara, Koichi Adachi, Yuji Takaoka, Takashi Iwamoto
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Cellular & Molecular Biology Letters
Subjects:
Reductive stress
microRNA
Cardiomyopathy
G6PD
p62/SQSTM1
JNK
Online Access:http://link.springer.com/article/10.1186/s11658-020-00232-x

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http://link.springer.com/article/10.1186/s11658-020-00232-x

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