Recombinant oncolytic adenovirus expressing a soluble PVR elicits long-term antitumor immune surveillance

Recombinant oncolytic adenovirus expressing a soluble PVR elicits long-term antitumor immune surveillance

Oncolytic virotherapy (OVT) has been suggested to be effective. However, the suppressive effects of checkpoints and insufficient costimulatory signals limit OVT-induced antitumor immune responses. In this study, we constructed a replicative adenovirus, Ad5sPVR, that expresses the soluble extracellul...

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Bibliographic Details
Main Authors: Hailin Zhang, Yonghui Zhang, Jie Dong, Binghua Li, Chun Xu, Min Wei, Junhua Wu, Jiwu Wei
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Oncolytics
Subjects:
oncolytic virus
PVR/CD155
T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain
TIGIT
immune checkpoints
CD226
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770520301662

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http://www.sciencedirect.com/science/article/pii/S2372770520301662

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