Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses

Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses

Anastomotic leakage (AL) accounts for a major part of in-house mortality in patients undergoing colorectal surgery. Local ischemia and abdominal sepsis are common risk factors contributing to AL and are characterized by upregulation of the hypoxia-inducible factor (HIF) pathway. The HIF pathway is c...

Full description

Bibliographic Details
Main Authors: Moritz J. Strowitzki, Gwendolyn Kimmer, Julian Wehrmann, Alina S. Ritter, Praveen Radhakrishnan, Vanessa M. Opitz, Christopher Tuffs, Marvin Biller, Julia Kugler, Ulrich Keppler, Jonathan M. Harnoss, Johannes Klose, Thomas Schmidt, Alfonso Blanco, Cormac T. Taylor, Martin Schneider
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-04-01
Series:JCI Insight
Subjects:
Gastroenterology
Inflammation
Online Access:https://doi.org/10.1172/jci.insight.139191

Internet

https://doi.org/10.1172/jci.insight.139191

Similar Items