A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus

Although CTCF binding has been implicated in the formation of topologically associated domains (TADs) the mechanisms folding the genome into TADs are not fully understood. Here the authors investigate the TAD boundary on lncRNA locus Firre, which has ~ 15 CTCF binding sites, and its organization.

Bibliographic Details
Main Authors: A. Rasim Barutcu, Philipp G. Maass, Jordan P. Lewandowski, Catherine L. Weiner, John L. Rinn
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03614-0