Inhibiting miR-22 Alleviates Cardiac Dysfunction by Regulating Sirt1 in Septic Cardiomyopathy

Inhibiting miR-22 Alleviates Cardiac Dysfunction by Regulating Sirt1 in Septic Cardiomyopathy

High morbidity and mortality are the most typical characteristics of septic cardiomyopathy. We aimed to reveal the role of miR-22 in septic cardiomyopathy and to explore the underlying mechanisms. miR-22 cardiac-specific knockout (miR-22cKO) mice and miR-22 cardiac-specific transgenic (miR-22cOE) mi...

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Bibliographic Details
Main Authors: Runze Wang, Yuerong Xu, Wei Zhang, Yexian Fang, Tiqun Yang, Di Zeng, Ting Wei, Jing Liu, Haijia Zhou, Yan Li, Zhan-peng Huang, Mingming Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
miR-22
autophagy
apoptosis
septic cardiomyopathy
sirt1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.650666/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.650666/full

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