Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis

Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis

Summary: Transcriptional silencing of the FMR1 gene in fragile X syndrome (FXS) leads to the loss of the RNA-binding protein FMRP. In addition to regulating mRNA translation and protein synthesis, emerging evidence suggests that FMRP acts to coordinate proliferation and differentiation during early...

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Bibliographic Details
Main Authors: Nisha Raj, Zachary T. McEachin, William Harousseau, Ying Zhou, Feiran Zhang, Megan E. Merritt-Garza, J. Matthew Taliaferro, Magdalena Kalinowska, Samuele G. Marro, Chadwick M. Hales, Elizabeth Berry-Kravis, Marisol W. Wolf-Ochoa, Veronica Martinez-Cerdeño, Marius Wernig, Lu Chen, Eric Klann, Stephen T. Warren, Peng Jin, Zhexing Wen, Gary J. Bassell
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
Fragile X syndrome
FMRP
autism
neurogenesis
protein synthesis
translation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721003053

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http://www.sciencedirect.com/science/article/pii/S2211124721003053

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