Polymorphism of the Transcription Factor 7-Like 2 Gene (TCF7L2) Interacts with Obesity on Type-2 Diabetes in the PREDIMED Study Emphasizing the Heterogeneity of Genetic Variants in Type-2 Diabetes Risk Prediction: Time for Obesity-Specific Genetic Risk Scores

Polymorphism of the Transcription Factor 7-Like 2 Gene (TCF7L2) Interacts with Obesity on Type-2 Diabetes in the PREDIMED Study Emphasizing the Heterogeneity of Genetic Variants in Type-2 Diabetes Risk Prediction: Time for Obesity-Specific Genetic Risk Scores

Nutrigenetic studies analyzing gene–diet interactions of the TCF7L2-rs7903146 C > T polymorphism on type-2 diabetes (T2D) have shown controversial results. A reason contributing to this may be the additional modulation by obesity. Moreover, TCF7L2-rs7903146 is one of the most influential vari...

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Bibliographic Details
Main Authors: Dolores Corella, Oscar Coltell, Jose V. Sorlí, Ramón Estruch, Laura Quiles, Miguel Ángel Martínez-González, Jordi Salas-Salvadó, Olga Castañer, Fernando Arós, Manuel Ortega-Calvo, Lluís Serra-Majem, Enrique Gómez-Gracia, Olga Portolés, Miquel Fiol, Javier Díez Espino, Josep Basora, Montserrat Fitó, Emilio Ros, José M. Ordovás
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:Nutrients
Subjects:
TCF7L2
type-2 diabetes
obesity
T2D-genetic risk scores
TCF7L2-predictive value
PREDIMED study
Online Access:http://www.mdpi.com/2072-6643/8/12/793

Internet

http://www.mdpi.com/2072-6643/8/12/793

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