PCSK9 variation and association with blood pressure in African Americans: preliminary findings from the HyperGEN and REGARDS studies

PCSK9 variation and association with blood pressure in African Americans: preliminary findings from the HyperGEN and REGARDS studies

Proprotein convertase subtilisin/kexin type 9 (encoded by PCSK9) plays a well-known role in the regulation of low-density lipoprotein (LDL) receptors, and an inhibitor of this enzyme is a promising new therapeutic for hyperlipidemia. Recently, animal and human studies also implicate PCSK9 genetic va...

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Bibliographic Details
Main Authors: Ngan T Tran, Stella eAslibekyan, Hemant K Tiwari, Degui eZhi, Yun Ju Sung, DC eRao, Steven C. Hunt, Ulrich eBroeckel, Donna K Arnett, Suzanne E Judd, Paul eMuntner, Shia T Kent, Ryan eIrvin
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Genetics
Subjects:
Blood Pressure
Hypertension
Dyslipidemia
pcsk9
Low-density lipoprotein cholesterol
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00136/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00136/full

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