LSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer

LSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer

Abstract Background Lysine-specific demethylase 1A (LSD1) is a key regulator of the androgen (AR) and estrogen receptors (ER), and LSD1 levels correlate with tumor aggressiveness. Here, we demonstrate that LSD1 regulates vitamin D receptor (VDR) activity and is a mediator of 1,25(OH)2-D3 (vitamin D)...

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Bibliographic Details
Main Authors: Sebastiano Battaglia, Ellen Karasik, Bryan Gillard, Jennifer Williams, Trisha Winchester, Michael T. Moser, Dominic J Smiraglia, Barbara A. Foster
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Clinical Epigenetics
Online Access:http://link.springer.com/article/10.1186/s13148-017-0382-y

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http://link.springer.com/article/10.1186/s13148-017-0382-y

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