LncRNAs GIHCG and SPINT1-AS1 Are Crucial Factors for Pan-Cancer Cells Sensitivity to Lapatinib

LncRNAs GIHCG and SPINT1-AS1 Are Crucial Factors for Pan-Cancer Cells Sensitivity to Lapatinib

Lapatinib is a small molecule inhibitor of EGFR (HER1) and ERBB2 (HER2) receptors, which is used for treatment of advanced or metastatic breast cancer. To find the drug resistance mechanisms of treatment for EGFR/ERBB2 positive tumors, we analyzed the possible effects of lncRNAs. In this study, usin...

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Bibliographic Details
Main Authors: Zhen Xiang, Shuzheng Song, Zhenggang Zhu, Wenhong Sun, Jaron E. Gifts, Sam Sun, Qiushi Shauna Li, Yingyan Yu, Keqin Kathy Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Genetics
Subjects:
pan-cancer
computational analysis
LncRNAs
lapatinib
targeted therapy
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00025/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00025/full

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