High-Throughput Mass Spectrometry Applied to Structural Genomics

High-Throughput Mass Spectrometry Applied to Structural Genomics

Mass spectrometry (MS) remains under-utilized for the analysis of expressed proteins because it is inaccessible to the non-specialist, and sample-turnaround from service labs is slow. Here, we describe 3.5 min Liquid-Chromatography (LC)-MS and 16 min LC-MSMS methods which are tailored to validation...

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Bibliographic Details
Main Authors: Rod Chalk, Georgina Berridge, Leela Shrestha, Claire Strain-Damerell, Pravin Mahajan, Wyatt W. Yue, Opher Gileadi, Nicola A. Burgess-Brown
Format: Article
Language:English
Published: MDPI AG 2014-10-01
Series:Chromatography
Subjects:
high-throughput
mass spectrometry
protein expression
structural genomics
integral membrane protein (IMP)
post-translational modification (PTM)
intact mass
Online Access:http://www.mdpi.com/2227-9075/1/4/159

Internet

http://www.mdpi.com/2227-9075/1/4/159

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