Protective effects of rolipram on endotoxic cardiac dysfunction via inhibition of the inflammatory response in cardiac fibroblasts

Protective effects of rolipram on endotoxic cardiac dysfunction via inhibition of the inflammatory response in cardiac fibroblasts

Abstract Background Cardiac fibroblasts, regarded as the immunomodulatory hub of the heart, have been thought to play an important role during sepsis-induced cardiomyopathy (SIC). However, the detailed molecular mechanism and targeted therapies for SIC are still lacking. Therefore, we sought to inve...

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Bibliographic Details
Main Authors: Jingjing Ji, Zhifeng Liu, Xinxin Hong, Zheying Liu, Jinghua Gao, Jinghua Liu
Format: Article
Language:English
Published: BMC 2020-05-01
Series:BMC Cardiovascular Disorders
Subjects:
Sepsis induced cardiomyopathy
Rolipram
Inflammatory mediators
Cardiac fibroblasts
Dual specificity phosphatase 1
Online Access:http://link.springer.com/article/10.1186/s12872-020-01529-7

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http://link.springer.com/article/10.1186/s12872-020-01529-7

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