Measurable Residual Disease Assessed by Flow-Cytometry Is a Stable Prognostic Factor for Pediatric T-Cell Acute Lymphoblastic Leukemia in Consecutive SEHOP Protocols Whereas the Impact of Oncogenetics Depends on Treatment

Measurable Residual Disease Assessed by Flow-Cytometry Is a Stable Prognostic Factor for Pediatric T-Cell Acute Lymphoblastic Leukemia in Consecutive SEHOP Protocols Whereas the Impact of Oncogenetics Depends on Treatment

Robust and applicable risk-stratifying genetic factors at diagnosis in pediatric T-cell acute lymphoblastic leukemia (T-ALL) are still lacking, and most protocols rely on measurable residual disease (MRD) assessment. In our study, we aimed to analyze the impact of NOTCH1, FBXW7, PTEN, and RAS mutati...

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Main Authors: Nerea Vega-García, Sara Perez-Jaume, Elena Esperanza-Cebollada, Clara Vicente-Garcés, Montserrat Torrebadell, Antonio Jiménez-Velasco, Margarita Ortega, Marta Llop, Lorea Abad, José Manuel Vagace, Alfredo Minguela, Marta Pratcorona, Joaquín Sánchez-Garcia, Clara B. García-Calderón, María Teresa Gómez-Casares, Estela Martín-Clavero, Adela Escudero, Marta Riñón Martinez-Gallo, Luz Muñoz, María Rosario Velasco, Marina García-Morin, Albert Català, Antonia Pascual, Pablo Velasco, José Mª. Fernández, Alvaro Lassaletta, José Luis Fuster, Isabel Badell, Águeda Molinos-Quintana, Antonio Molinés, Pilar Guerra-García, Antonio Pérez-Martínez, Miriam García-Abós, Reyes Robles Ortiz, Sandra Pisa, Rosa Adán, Cristina Díaz de Heredia, José Luis Dapena, Susana Rives, Manuel Ramírez-Orellana, Mireia Camós
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pediatrics
Subjects:
measurable (minimal) residual disease
T-cell acute lymphoblastic leukemia
oncogenetics
NOTCH1
flow cytometry
pediatrics
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2020.614521/full

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https://www.frontiersin.org/articles/10.3389/fped.2020.614521/full

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