The combined effects of microglia activation and brain glucose hypometabolism in early-onset Alzheimer’s disease

The combined effects of microglia activation and brain glucose hypometabolism in early-onset Alzheimer’s disease

Abstract Background Early-onset Alzheimer’s disease (EOAD) is characterized by young age of onset (< 65 years), severe neurodegeneration, and rapid disease progression, thus differing significantly from typical late-onset Alzheimer’s disease. Growing evidence suggests a primary role of neuroinfla...

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Bibliographic Details
Main Authors: Giacomo Tondo, Leonardo Iaccarino, Silvia Paola Caminiti, Luca Presotto, Roberto Santangelo, Sandro Iannaccone, Giuseppe Magnani, Daniela Perani
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Alzheimer’s Research & Therapy
Subjects:
Positron emission tomography
Early-onset Alzheimer’s disease
[18F]-FDG PET
[11C]-(R)-PK11195 PET
Microglia activation
Online Access:http://link.springer.com/article/10.1186/s13195-020-00619-0

Internet

http://link.springer.com/article/10.1186/s13195-020-00619-0

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