Targeted inhibition of ERα signaling and PIP5K1α/Akt pathways in castration‐resistant prostate cancer

Targeted inhibition of ERα signaling and PIP5K1α/Akt pathways in castration‐resistant prostate cancer

Selective ERα modulator, tamoxifen, is well tolerated in a heavily pretreated castration‐resistant prostate cancer (PCa) patient cohort. However, its targeted gene network and whether expression of intratumor ERα due to androgen deprivation therapy (ADT) may play a role in PCa progression is unknown...

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Bibliographic Details
Main Authors: Julius Semenas, Tianyan Wang, Azharuddin Sajid Syed Khaja, AKM Firoj Mahmud, Athanasios Simoulis, Thomas Grundström, Maria Fällman, Jenny L. Persson
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:Molecular Oncology
Subjects:
castration‐resistant prostate cancer
estrogen receptor
PI3K/AKT pathway and tamoxifen
PIP5K1α
targeted therapy
Online Access:https://doi.org/10.1002/1878-0261.12873

Internet

https://doi.org/10.1002/1878-0261.12873

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