Impaired clearance and enhanced pulmonary inflammatory/fibrotic response to carbon nanotubes in myeloperoxidase-deficient mice.

Impaired clearance and enhanced pulmonary inflammatory/fibrotic response to carbon nanotubes in myeloperoxidase-deficient mice.

Advancement of biomedical applications of carbonaceous nanomaterials is hampered by their biopersistence and pro-inflammatory action in vivo. Here, we used myeloperoxidase knockout B6.129X1-MPO (MPO k/o) mice and showed that oxidation and clearance of single walled carbon nanotubes (SWCNT) from the...

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Bibliographic Details
Main Authors: Anna A Shvedova, Alexandr A Kapralov, Wei Hong Feng, Elena R Kisin, Ashley R Murray, Robert R Mercer, Claudette M St Croix, Megan A Lang, Simon C Watkins, Nagarjun V Konduru, Brett L Allen, Jennifer Conroy, Gregg P Kotchey, Bashir M Mohamed, Aidan D Meade, Yuri Volkov, Alexander Star, Bengt Fadeel, Valerian E Kagan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3316527?pdf=render

Internet

http://europepmc.org/articles/PMC3316527?pdf=render

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