The SUMO Isopeptidase SENP6 Functions as a Rheostat of Chromatin Residency in Genome Maintenance and Chromosome Dynamics

The SUMO Isopeptidase SENP6 Functions as a Rheostat of Chromatin Residency in Genome Maintenance and Chromosome Dynamics

Summary: Signaling by the ubiquitin-related SUMO pathway relies on coordinated conjugation and deconjugation events. SUMO-specific deconjugating enzymes counterbalance SUMOylation, but comprehensive insight into their substrate specificity and regulation is missing. By characterizing SENP6, we defin...

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Bibliographic Details
Main Authors: Kristina Wagner, Kathrin Kunz, Tanja Piller, Georg Tascher, Soraya Hölper, Per Stehmeier, Jan Keiten-Schmitz, Markus Schick, Ulrich Keller, Stefan Müller
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719311684

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http://www.sciencedirect.com/science/article/pii/S2211124719311684

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