The role of Ca2+/calmodulin-dependent protein kinase II and calcineurin in TNF-α-induced myocardial hypertrophy

The role of Ca2+/calmodulin-dependent protein kinase II and calcineurin in TNF-α-induced myocardial hypertrophy

We investigated whether Ca2+/calmodulin-dependent kinase II (CaMKII) and calcineurin (CaN) are involved in myocardial hypertrophy induced by tumor necrosis factor α (TNF-α). The cardiomyocytes of neonatal Wistar rats (1-2 days old) were cultured and stimulated by TNF-α (10...

Full description

Bibliographic Details
Main Authors: Gui-Jun Wang, Hong-Xin Wang, Yu-Sheng Yao, Lian-Yi Guo, Pei Liu
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2012-11-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Myocardial hypertrophy
Tumor necrosis factor α
Calcium
Calmodulin-dependent kinase
Calcineurin
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001100008

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001100008

Similar Items