AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma

AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma

Abstract Background The maintenance of complex dendritic arbors and synaptic transmission are processes that require a substantial amount of energy. Bioenergetic decline is a prominent feature of chronic neurodegenerative diseases, yet the signaling mechanisms that link energy stress with neuronal d...

Full description

Bibliographic Details
Main Authors: Nicolas Belforte, Jessica Agostinone, Luis Alarcon-Martinez, Deborah Villafranca-Baughman, Florence Dotigny, Jorge L. Cueva Vargas, Adriana Di Polo
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Molecular Neurodegeneration
Subjects:
Adenosine monophosphate-activated protein kinase
Metabolic stress
Mammalian target of rapamycin
Glaucoma
Neurodegeneration
Online Access:https://doi.org/10.1186/s13024-021-00466-z

Internet

https://doi.org/10.1186/s13024-021-00466-z

Similar Items