MeDEStrand: an improved method to infer genome-wide absolute methylation levels from DNA enrichment data

MeDEStrand: an improved method to infer genome-wide absolute methylation levels from DNA enrichment data

Abstract Background DNA methylation of CpG dinucleotides is an essential epigenetic modification that plays a key role in transcription. Widely used DNA enrichment-based methods offer high coverage for measuring methylated CpG dinucleotides, with the lowest cost per CpG covered genome-wide. However,...

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Bibliographic Details
Main Authors: Jingting Xu, Shimeng Liu, Ping Yin, Serdar Bulun, Yang Dai
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Bioinformatics
Subjects:
DNA methylation
MeDIP-seq
RRBS
CpG bias
Sigmoid function
Online Access:http://link.springer.com/article/10.1186/s12859-018-2574-7

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http://link.springer.com/article/10.1186/s12859-018-2574-7

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