Sox9 augments BMP2-induced chondrogenic differentiation by downregulating Smad7 in mesenchymal stem cells (MSCs)

Sox9 augments BMP2-induced chondrogenic differentiation by downregulating Smad7 in mesenchymal stem cells (MSCs)

Cartilage injuries caused by arthritis or trauma pose formidable challenges for effective clinical management due to the limited intrinsic proliferative capability of chondrocytes. Autologous stem cell-based therapies and transgene-enhanced cartilage tissue engineering may open new avenues for the t...

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Bibliographic Details
Main Authors: Chen Zhao, Wei Jiang, Nian Zhou, Junyi Liao, Mingming Yang, Ning Hu, Xi Liang, Wei Xu, Hong Chen, Wei Liu, Lewis L. Shi, Leonardo Oliveira, Jennifer Moriatis Wolf, Sherwin Ho, Aravind Athiviraham, H.M. Tsai, Tong-Chuan He, Wei Huang
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Genes and Diseases
Subjects:
Bone morphogenetic protein 2 (BMP2)
Cartilage tissue engineering
Chondrogenic differentiation
Endochondral ossification
Mesenchymal stem cells (MSCs)
Smad7
Sox9
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304217300697

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http://www.sciencedirect.com/science/article/pii/S2352304217300697

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