Glutathione reductase deficiency alters lung development and hyperoxic responses in neonatal mice

Glutathione reductase deficiency alters lung development and hyperoxic responses in neonatal mice

Cellular antioxidants protect against hyperoxic lung injury. The role of the glutathione (GSH) system in lung development and bronchopulmonary dysplasia (BPD) pathogenesis has not been systematically investigated. The current study utilized GSH reductase-deficient (Gsr-KO) neonatal mice to test the...

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Bibliographic Details
Main Authors: Mary E. Robbins, Hye-Youn Cho, Jason M. Hansen, Joseph R. Luchsinger, Morgan L. Locy, Markus Velten, Steven R. Kleeberger, Lynette K. Rogers, Trent E. Tipple
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Redox Biology
Subjects:
Glutathione reductase
Mice
Hyperoxia
Bronchopulmonary dysplasia
Thioredoxin
Neonate
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720310028

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http://www.sciencedirect.com/science/article/pii/S2213231720310028

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