Astrocytes have the capacity to act as antigen-presenting cells in the Parkinson’s disease brain

Astrocytes have the capacity to act as antigen-presenting cells in the Parkinson’s disease brain

Abstract Background Many lines of evidence suggest that accumulation of aggregated alpha-synuclein (αSYN) in the Parkinson’s disease (PD) brain causes infiltration of T cells. However, in which ways the stationary brain cells interact with the T cells remain elusive. Here, we identify astrocytes as...

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Bibliographic Details
Main Authors: Jinar Rostami, Grammatiki Fotaki, Julien Sirois, Ropafadzo Mzezewa, Joakim Bergström, Magnus Essand, Luke Healy, Anna Erlandsson
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Neuroinflammation
Subjects:
Astrocytes
T-cell infiltration
MHC-II
Antigen presentation
Alpha-synuclein
Parkinson’s disease
Online Access:http://link.springer.com/article/10.1186/s12974-020-01776-7

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http://link.springer.com/article/10.1186/s12974-020-01776-7

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