Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease.

Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease.

BACKGROUND:Cellular senescence can be a functional barrier to carcinogenesis. We hypothesized that inflammation modulates carcinogenesis through senescence and DNA damage response (DDR). We examined the association between senescence and DDR with macrophage levels in inflammatory bowel disease (IBD)...

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Bibliographic Details
Main Authors: Jane J Sohn, Aaron J Schetter, Harris G Yfantis, Lisa A Ridnour, Izumi Horikawa, Mohammed A Khan, Ana I Robles, S Perwez Hussain, Akiteru Goto, Elise D Bowman, Lorne J Hofseth, Jirina Bartkova, Jiri Bartek, Gerald N Wogan, David A Wink, Curtis C Harris
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3435404?pdf=render

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http://europepmc.org/articles/PMC3435404?pdf=render

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