Trop-2 cleavage by ADAM10 is an activator switch for cancer growth and metastasis

Trop-2 cleavage by ADAM10 is an activator switch for cancer growth and metastasis

Trop-2 is a transmembrane signal transducer that can induce cancer growth. Using antibody targeting and N-terminal Edman degradation, we show here that Trop-2 undergoes cleavage in the first thyroglobulin domain loop of its extracellular region, between residues R87 and T88. Molecular modeling indic...

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Bibliographic Details
Main Authors: Marco Trerotola, Emanuela Guerra, Zeeshan Ali, Anna Laura Aloisi, Martina Ceci, Pasquale Simeone, Angela Acciarito, Paola Zanna, Giovanna Vacca, Antonella D'Amore, Khouloud Boujnah, Valeria Garbo, Antonino Moschella, Rossano Lattanzio, Saverio Alberti
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Trop
Proteolytic processing
Signaling activation
Cell growth
Molecular modeling
Human cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558621000166

Internet

http://www.sciencedirect.com/science/article/pii/S1476558621000166

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