Dynamic metabolic modelling of overproduced protein secretion in Streptomyces lividans using adaptive DFBA

Abstract Background Streptomyces lividans is an appealing host for the production of proteins of biotechnological interest due to its relaxed exogenous DNA restriction system and its ability to secrete proteins directly to the medium through the major Sec or the minor Tat routes. Often, protein secr...

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Bibliographic Details
Main Authors: Jósé R. Valverde, Sonia Gullón, Clara A. García-Herrero, Iván Campoy, Rafael P. Mellado
Format: Article
Language:English
Published: BMC 2019-10-01
Series:BMC Microbiology
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12866-019-1591-7