Magnesium Absorption in Intestinal Cells: Evidence of Cross-Talk between EGF and TRPM6 and Novel Implications for Cetuximab Therapy

Magnesium Absorption in Intestinal Cells: Evidence of Cross-Talk between EGF and TRPM6 and Novel Implications for Cetuximab Therapy

Hypomagnesemia is very commonly observed in cancer patients, most frequently in association with therapy with cetuximab (CTX), a monoclonal antibody targeting the epithelial growth factor receptor (EGFR). CTX-induced hypomagnesemia has been ascribed to renal magnesium (Mg) wasting. Here, we sought t...

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Bibliographic Details
Main Authors: Giuseppe Pietropaolo, Daniela Pugliese, Alessandro Armuzzi, Luisa Guidi, Antonio Gasbarrini, Gian Lodovico Rapaccini, Federica I. Wolf, Valentina Trapani
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Nutrients
Subjects:
biomarker
colorectal cancer
EGFR
hypomagnesemia
magnesium supplementation
monoclonal antibodies
Online Access:https://www.mdpi.com/2072-6643/12/11/3277

Internet

https://www.mdpi.com/2072-6643/12/11/3277

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