Prolonged blockade of NMDA or mGluR5 glutamate receptors reduces nigrostriatal degeneration while inducing selective metabolic changes in the basal ganglia circuitry in a rodent model of Parkinson's disease

Prolonged blockade of NMDA or mGluR5 glutamate receptors reduces nigrostriatal degeneration while inducing selective metabolic changes in the basal ganglia circuitry in a rodent model of Parkinson's disease

We compared the neuroprotective and metabolic effects of chronic treatment with ionotropic or metabotropic glutamate receptor antagonists, in rats bearing a unilateral nigrostriatal lesion induced by 6-hydroxydopamine (6-OHDA). The ionotropic, N-methyl-d-aspartate receptor antagonist MK-801 increase...

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Bibliographic Details
Main Authors: Marie-Thérèse Armentero, Roberto Fancellu, Giuseppe Nappi, Placido Bramanti, Fabio Blandini
Format: Article
Language:English
Published: Elsevier 2006-04-01
Series:Neurobiology of Disease
Subjects:
6-Hydroxydopamine
Basal ganglia
Neuroprotection
Tyrosine hydroxylase
Cytochrome oxidase
Ionotropic
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105002664

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http://www.sciencedirect.com/science/article/pii/S0969996105002664

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