Potential toxicity of quercetin: The repression of mitochondrial copy number via decreased POLG expression and excessive TFAM expression in irradiated murine bone marrow

Potential toxicity of quercetin: The repression of mitochondrial copy number via decreased POLG expression and excessive TFAM expression in irradiated murine bone marrow

The cytotoxicity of quercetin is not well understood. Using an ICR murine model, we unexpectedly found that mice exposed to 7 Gy total body irradiation (TBI) exhibited general in vivo toxicity after receiving quercetin (100 mg/kg PO), whereas this result was not observed in mice that received TBI on...

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Bibliographic Details
Main Authors: Ruiqing Chen, Jingan Lin, Jingshen Hong, Deping Han, Addison D. Zhang, Ruilong Lan, Lengxi Fu, Zhaoyang Wu, Jianhua Lin, Weijian Zhang, Zeng Wang, Wei Chen, Chun Chen, Hengshan Zhang
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Toxicology Reports
Subjects:
Quercetin
Radiation
Mitochondrial DNA copy number
POLG
POLG2
TFAM
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750014000596

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http://www.sciencedirect.com/science/article/pii/S2214750014000596

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