DNA vaccines encoding antigen targeted to MHC class II induce influenza specific CD8+ T cell responses, enabling faster resolution of influenza disease.

DNA vaccines encoding antigen targeted to MHC class II induce influenza specific CD8+ T cell responses, enabling faster resolution of influenza disease.

Current influenza vaccines are effective but imperfect, failing to cover against emerging strains of virus and requiring seasonal administration to protect against new strains. A key step to improving influenza vaccines is to improve our understanding of vaccine induced protection. Whilst it is clea...

Full description

Bibliographic Details
Main Authors: Laura Lambert, Ekaterina Kinnear, Jacqueline McDonald, Gunnveig Grødeland, Bjarne Bogen, Elisabeth Stubsrud, Mona Lindeberg, Agnete Brunsvik Fredriksen, John S Tregoning
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Immunology
Subjects:
CD8-Positive T-Lymphocytes
Influenza Vaccines
DNA Vaccines
MHC II
Immune targeting
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00321/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00321/full

Similar Items