Design and Characterization of a Peptide Mimotope of the HIV-1 gp120 Bridging Sheet

Design and Characterization of a Peptide Mimotope of the HIV-1 gp120 Bridging Sheet

The Bridging Sheet domain of HIV-1 gp120 is highly conserved among the HIV-1 strains and allows HIV-1 binding to host cells via the HIV-1 coreceptors. Further, the bridging sheet domain is a major target to neutralize HIV-1 infection. We rationally designed four linear peptide epitopes that mimic th...

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Bibliographic Details
Main Authors: Guido Poli, Giuseppe Scala, Ileana Quinto, Vincenzo Pavone, Piergiuseppe de Berardinis, Giulia Morsica, Maria Trovato, Jan Rafay, Boris Ferko, Concetta Andreozzi, Angela Lombardi, David Montefiori, Annarita Scialdone, Eleonora Vecchio, Annalisa Rossi, Camillo Palmieri, Antonio Pisano, Marilena Pontoriero, Enrico Iaccino, Selena Mimmi, Francesca Fasanella Masci, Cristina Falcone, Giuseppe Fiume, Antonella Caivano, Annamaria de Laurentiis, Marco Schiavone
Format: Article
Language:English
Published: MDPI AG 2012-05-01
Series:International Journal of Molecular Sciences
Subjects:
HIV-1 vaccine
bridging sheet
mimotope
Online Access:http://www.mdpi.com/1422-0067/13/5/5674

Internet

http://www.mdpi.com/1422-0067/13/5/5674

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