A-to-I RNA editing in the rat brain is age-dependent, region-specific and sensitive to environmental stress across generations

A-to-I RNA editing in the rat brain is age-dependent, region-specific and sensitive to environmental stress across generations

Abstract Background Adenosine-to-inosine (A-to-I) RNA editing is an epigenetic modification catalyzed by adenosine deaminases acting on RNA (ADARs), and is especially prevalent in the brain. We used the highly accurate microfluidics-based multiplex PCR sequencing (mmPCR-seq) technique to assess the...

Full description

Bibliographic Details
Main Authors: Hiba Zaidan, Gokul Ramaswami, Yaela N. Golumbic, Noa Sher, Assaf Malik, Michal Barak, Dalia Galiani, Nava Dekel, Jin B. Li, Inna Gaisler-Salomon
Format: Article
Language:English
Published: BMC 2018-01-01
Series:BMC Genomics
Subjects:
RNA editing
Stress
Transgenerational
Serotonin receptor 2C
Rat
Brain
Online Access:http://link.springer.com/article/10.1186/s12864-017-4409-8

Internet

http://link.springer.com/article/10.1186/s12864-017-4409-8

Similar Items