Effects of Single Amino Acid Substitution on the Biophysical Properties and Biological Activities of an Amphipathic α-Helical Antibacterial Peptide Against Gram-Negative Bacteria

Effects of Single Amino Acid Substitution on the Biophysical Properties and Biological Activities of an Amphipathic α-Helical Antibacterial Peptide Against Gram-Negative Bacteria

An antimicrobial peptide, known as V13K, was utilized as the framework to study the effects of charge, hydrophobicity and helicity on the biophysical properties and biological activities of α-helical peptides. Six amino acids (Lys, Glu, Gly, Ser, Ala, and Leu) were individually used to substitute th...

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Bibliographic Details
Main Authors: Juanjuan Tan, Jinfeng Huang, Yibing Huang, Yuxin Chen
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:Molecules
Subjects:
antimicrobial peptide
hydrophobicity
biological activity
Gram-negative bacteria
mechanism of action
Online Access:http://www.mdpi.com/1420-3049/19/8/10803

Internet

http://www.mdpi.com/1420-3049/19/8/10803

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