A Functional Assay for Sick Sinus Syndrome Genetic Variants

A Functional Assay for Sick Sinus Syndrome Genetic Variants

Background/Aims: Congenital Sick Sinus Syndrome (SSS) is a disorder associated with sudden cardiac death due to severe bradycardia and prolonged pauses. Mutations in HCN4, the gene encoding inward Na+/K+ current (If), have been described as a cause of congenital SSS. The objective of this study is t...

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Bibliographic Details
Main Authors: Chuanchau J. Jou, Cammon B. Arrington, Spencer Barnett, Jiaxiang Shen, Scott Cho, Xiaoming Sheng, Patrick C. McCullagh, Neil E. Bowles, Chase M. Pribble, Elizabeth V. Saarel, Thomas A. Pilcher, Susan P. Etheridge, Martin Tristani-Firouzi
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Arrhythmia
Genetics
Sick sinus syndrome
Zebrafish
Sudden cardiac death
Online Access:http://www.karger.com/Article/FullText/479897

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http://www.karger.com/Article/FullText/479897

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