Prevention and Reversal of Antibody Responses Against Factor IX in Gene Therapy for Hemophilia B

Prevention and Reversal of Antibody Responses Against Factor IX in Gene Therapy for Hemophilia B

Intramuscular (IM) administration of an adeno-associated viral (AAV) vector represents a simple and safe method of gene transfer for treatment of the X-linked bleeding disorder hemophilia B (factor IX, F.IX, deficiency). However, the approach is hampered by an increased risk of immune responses agai...

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Bibliographic Details
Main Authors: Sushrusha eNayak, Debalina eSarkar, George Q. Perrin, Babak eMoghimi, Brad E Hoffman, Shangzhen eZhou, Barry J. Byrne, Roland W. Herzog
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-12-01
Series:Frontiers in Microbiology
Subjects:
Factor IX
Gene Therapy
tolerance
antibody
Muscle
Hemophilia
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00244/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00244/full

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