Age-dependent changes in protein incorporation into collagen-rich tissues of mice by in vivo pulsed SILAC labelling

Age-dependent changes in protein incorporation into collagen-rich tissues of mice by in vivo pulsed SILAC labelling

Collagen-rich tissues have poor reparative capacity that predisposes to common age-related disorders such as osteoporosis and osteoarthritis. We used in vivo pulsed SILAC labelling to quantify new protein incorporation into cartilage, bone, and skin of mice across the healthy life course. We report...

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Bibliographic Details
Main Authors: Yoanna Ariosa-Morejon, Alberto Santos, Roman Fischer, Simon Davis, Philip Charles, Rajesh Thakker, Angus KT Wann, Tonia L Vincent
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-09-01
Series:eLife
Subjects:
Age
protein dynamics
proteomics
SILAC
matrisome
collagen-rich tissues
Online Access:https://elifesciences.org/articles/66635

Internet

https://elifesciences.org/articles/66635

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