The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection

The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection

Antibiotics are widely used in the treatment of bacterial infections. Although known for their microbicidal activity, antibiotics may also interfere with the host’s immune system. Here, we analyzed the effects of bedaquiline (BDQ), an inhibitor of the mycobacterial ATP synthase, on human macrophages...

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Bibliographic Details
Main Authors: Alexandre Giraud-Gatineau, Juan Manuel Coya, Alexandra Maure, Anne Biton, Michael Thomson, Elliott M Bernard, Jade Marrec, Maximiliano G Gutierrez, Gérald Larrouy-Maumus, Roland Brosch, Brigitte Gicquel, Ludovic Tailleux
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-05-01
Series:eLife
Subjects:
host-pathogen interaction
innate immunity
macrophages
tuberculosis
antibiotics
Online Access:https://elifesciences.org/articles/55692

Internet

https://elifesciences.org/articles/55692

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