Commonly Used Pancreatic Stellate Cell Cultures Differ Phenotypically and in Their Interactions with Pancreatic Cancer Cells

Commonly Used Pancreatic Stellate Cell Cultures Differ Phenotypically and in Their Interactions with Pancreatic Cancer Cells

Activated pancreatic stellate cells (PSCs) play a central role in the tumor stroma of pancreatic ductal adenocarcinoma (PDAC). Given the limited availability of patient-derived PSCs from PDAC, immortalized PSC cell lines of murine and human origin have been established; however, it is not elucidated...

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Bibliographic Details
Main Authors: Daniela Lenggenhager, Manoj Amrutkar, Petra Sántha, Monica Aasrum, Johannes-Matthias Löhr, Ivar P. Gladhaug, Caroline S. Verbeke
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cells
Subjects:
pancreatic stellate cells
pancreatic cancer
tumor-stroma interaction
TGF-β
Online Access:http://www.mdpi.com/2073-4409/8/1/23

Internet

http://www.mdpi.com/2073-4409/8/1/23

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