Antibody-mediated activation of FGFR1 induces FGF23 production and hypophosphatemia.

Antibody-mediated activation of FGFR1 induces FGF23 production and hypophosphatemia.

The phosphaturic hormone Fibroblast Growth Factor 23 (FGF23) controls phosphate homeostasis by regulating renal expression of sodium-dependent phosphate co-transporters and cytochrome P450 enzymes involved in vitamin D catabolism. Multiple FGF Receptors (FGFRs) can act as receptors for FGF23 when bo...

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Bibliographic Details
Main Authors: Ai-Luen Wu, Bo Feng, Mark Z Chen, Ganesh Kolumam, Jose Zavala-Solorio, Shelby K Wyatt, Vineela D Gandham, Richard A D Carano, Junichiro Sonoda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3579827?pdf=render

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http://europepmc.org/articles/PMC3579827?pdf=render

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