Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer

Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer

Lineage transformation between lung cancer subtypes is a poorly understood phenomenon associated with resistance to treatment and poor patient outcomes. Here, we aimed to model this transition to define underlying biological mechanisms and identify potential avenues for therapeutic intervention. Sma...

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Bibliographic Details
Main Authors: Yusuke Inoue, Ana Nikolic, Dylan Farnsworth, Rocky Shi, Fraser D Johnson, Alvin Liu, Marc Ladanyi, Romel Somwar, Marco Gallo, William W Lockwood
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
lung cancer
lineage transformation
ERK signaling
Online Access:https://elifesciences.org/articles/66524

Internet

https://elifesciences.org/articles/66524

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